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Pharmacokinetic parameters of ibuprofen (30 mg/kg) following oral administration in rats. Results are expressed as the mean ± S.D (n = 5) ∗P < 0.05, compared with the control. NE, nanoemulsion; ME, microemulsion.
| Cmax (μg/ml) | Tmax (h) | T1/2(h) | AUC0–6h (μg/ml∙h) | |
|---|---|---|---|---|
| Control | 23.0 ± 1.4 | 1.0 | 1.87 ± 0.41 | 3060.3 ± 169.9 |
| NE | 53.5 ± 1.9 | 1.0 | 2.02 ± 0.28 | 6670.1 ± 283.8∗ |
| ME A | 42.4 ± 1.3 | 1.0 | 1.89 ± 0.27 | 5084.0 ± 246.3∗ |
| ME B | 28.9 ± 1.0 | 1.0 | 1.87 ± 0.41 | 4044.1 ± 79.0∗ |
