FIG 4.

Correlation between the inhibition of HIV-1 Env clones by SERINC5 and IFITM3 with the responses of HIV-1 Env clones to CD4 MAb, sCD4, and CCR5 inhibitor TAK-799. (A to C) Correlation analyses were performed between the folds of SERINC5 inhibition and the IC₅₀ values of T/F Env clones for CD4 MAb (A), sCD4 (B), and TAK-779 (C). The IC₅₀ values of these agents were obtained from the study by Keele et al. (30). (D) Correlation between the IC₅₀ values of sCD4 and TAK-779. (E to G) Correlation between the folds of inhibition by IFITM3 and the IC₅₀ values for CD4 MAb (E), sCD4 (F), and TAK-779 (G). Correlation were assessed using the Spearman rank test.