TABLE 3.

Response of chronic Env clones to the inhibition by SERINC5 and IFITM3

Chronic Enva	Subtype	Fold inhibition by SERINC5b	Fold inhibition by IFITM3c
X2278	B	1.64 ± 0.13	6.89 ± 1.72
CNE8	A/E	0.67 ± 0.02	3.27 ± 0.40
398F1	A	1.159 ± 0.07	6.4 ± 1.42
25710	C	1.8 ± 0.0.07	9.11 ± 1.35
CH119	B/C	0.33 ± 0.03	4.2 ± 0.57
246F3	A/C	0.31 ± 0.08	0.96 ± 0.27
CE1176	C	0.34 ± 0.02	13.368 ± 5.03
X1632	G	0.993 ± 0.10	12.238 ± 1.15
BJOX002000	B/C	1.12 ± 0.17	7.93 ± 1.37
CNE55	A/E	1.02 ± 0.27	5.3 ± 2.7
CE0217	C	1.37 ± 0.33	11.7 ± 1.33
TRO11	B	0.93 ± 0.24	4.13 ± 0.8
MF535.W0M.ENV.D11	D/A	1.35 ± 0.11	2.22 ± 0.2
MG505.W0M.ENV.H3	A	2.8 ± 1.4	15.26 ± 3.5
MI206.W0M.ENV.D1	A	0.86 ± 0.006	19.2 ± 0.7
ML035.W0M.ENV.I2	D/A	0.93 ± 0.08	19.6 ± 2.18

^aAll the Env clones are R5 tropic.

^bFold inhibition by SERINC5 was determined by calculating the ratio of infectivity of the SERINC5-free virus to that of the SERINC5-bearing virus.

^cFold inhibition by IFITM3 was determined by calculating the ratio of infectivity of the IFITM3-free virus to that of the IFITM3-bearing virus.