TABLE 2.
Association between SNPs with selection signals and human phenotypes
| Gene | SNP | Population | |iHS| | Reference allele | Alternate allele | Risk allele | P value | Traita |
|---|---|---|---|---|---|---|---|---|
| AP3D1 | rs75483641 | CEU | 2.0193 | C | T | T | 8 × 10−10 | Male-pattern baldness |
| AXL | rs4802111 | CEU | −2.0706 | C | T | C | 1 × 10−21 | Heel bone mineral density |
| CHB | −2.5279 | C | T | C | 1 × 10−21 | Heel bone mineral density | ||
| CACNA1C | rs216026 | CEU | 2.8285 | T | G | T | 8 × 10−6 | Fractional exhaled nitric oxide |
| rs11062222 | CEU | −2.2341 | A | G | A | 9 × 10−6 | Short-term memory | |
| rs7301013 | CEU | −1.9981 | A | G | A | 3 × 10−12 | Heel bone mineral density | |
| CD300LF | rs9906320 | CEU | 2.0893 | G | A | A | 3 × 10−9 | Plateletcrit |
| CD80 | rs6804441 | CEU | 2.4862 | A | G | A | 3 × 10−16 | Systemic lupus erythematosus |
| HLA-DRB1 | rs9256938 | CEU | −3.1420 | C | A | A | 2 × 10−12 | Blood protein levels |
| YRI | −3.4035 | C | A | A | 2 × 10−12 | Blood protein levels | ||
| rs34075049 | YRI | −3.5202 | G | A | A | 9 × 10−6 | Neurofibrillary tangles | |
| ITGA4 | rs12988934 | CHB | 2.1631 | C | T | T | 2 × 10−14 | White blood cell types |
| rs1375493 | YRI | 2.0981 | G | A | A | 1 × 10−10 | Lymphocyte percentage of white cells | |
| rs10209150 | YRI | −2.0076 | A | G | G | 6 × 10−6 | Neurofibrillary tangles | |
| ITGB8 | rs10231365 | YRI | 2.8091 | C | T | T | 9 × 10−9 | Waist circumference adjusted for BMI |
| rs4721902 | YRI | 2.5428 | T | C | T | 3 × 10−8 | Waist-to-hip ratio adjusted for BMI | |
| rs2214442 | YRI | 2.5235 | A | G | A | 2 × 10−7 | Waist circumference adjusted for BMI | |
| rs3823974 | YRI | −2.4516 | T | C | C | 3 × 10−21 | Body fat distribution | |
| LDLR | rs688 | CEU | 2.0982 | C | T | C | 1 × 10−25 | Total cholesterol levels |
| 5 × 10−30 | Low-density lipoprotein cholesterol levels | |||||||
| rs5927 | CHB | −2.6008 | A | G | A | 9 × 10−6 | Cortisol levels | |
| MERTK | rs4374383 | CHB | −2.6794 | A | G | A | 1 × 10−9 | Hepatitis C-induced liver fibrosis |
| MOG | rs2252711 | CEU | 2.7605 | T | C | T | 4 × 10−7 | Pulmonary function |
| NCAM1 | rs2186709 | CHB | 4.5103 | A | G | G | 2 × 10−24 | Age of smoking initiation |
| rs7110863 | CHB | −3.9668 | A | G | G | 3 × 10−11 | Smoking cessation | |
| rs7111153 | CHB | −3.7995 | T | C | T | 4 × 10−18 | Self-reported math ability | |
| rs17115088 | CHB | 2.7324 | C | A | C | 2 × 10−42 | Heel bone mineral density | |
| SLC19A2 | rs1983546 | CEU | −2.0123 | A | G | G | 1 × 10−15 | QT interval |
| SLC7A1 | rs9508495 | CEU | 2.0207 | C | T | T | 1 × 10−9 | Systolic blood pressure |
| rs3803266 | CEU | 2.0069 | G | C | G | 7 × 10−10 | Medication use |
a
BMI, body mass index.