TABLE 4.

Genes in eECs differentially induced by rSP and the MV fraction from infected individuals^a

rSP from HIV-infected individuals vs rSP from uninfected individuals			MVs from HIV-infected individuals vs MVs from uninfected individuals
Gene regulation and gene	P value	Fold change in expression	Gene regulation and gene	P value	Fold change in expression
Upregulated by rSP from HIV-infected individuals			Upregulated by MV from HIV-infected individuals
HIF1A-AS2	<0.001	3.48	HIST1H3E	0.02	2.45
VGF	0.02	2.20	FAM229A	0.04	1.80
FAM229A	0.03	1.52	HIST2H2AC	0.04	1.66
			RPL21P44	0.03	1.62
			RPS15AP10	0.01	1.59
			EXOC3-AS1	0.02	1.56
Downregulated by rSP from HIV-infected individuals			Downregulated by MV from HIV-infected individuals
KMT2	0.04	1.92	ZNF43	0.04	7.82
AOC2	0.04	1.86	MT1G	0.02	3.75
SPEN	0.04	1.86	MT1H	<0.001	2.79
AHNAK	0.05	1.72	CCDC89	0.04	1.81
CRIPAK	0.05	1.65	SST	0.01	1.54
LOC728752	<0.001	1.63
RSAD2	0.02	1.60
OAS2	<0.001	1.59
MSMP	0.02	1.54
OAS3	<0.001	1.54
EIF2AK2	0.03	1.54
SAMD9	0.02	1.51

^aGenes with a ≥1.5-fold change in expression between treatment groups with a P value of <0.05.