TABLE 5.

Selected gene pathways induced by eSFs and eECs exposed to rSP and the MV fraction from HIV-infected individuals^a

Comparison	Category	Function annotation	Activation state	Z-score
rSP vs mock exposure (eEC)	Cell death and survival	Cell death	Decreased	1.60
	Cell death and survival	Apoptosis	Decreased	1.54
	Cell signaling	Replication of viral replicon	Increased	1.98
	Cellular movement	Colony formation of cells	Increased	2.42
	Cellular movement	Tubulation of cells	Increased	1.96
rSP vs mock exposure (eSF)	Cell death and survival	Cell survival	Increased	2.89
	Cell death and survival	Activation of cells	Increased	2.75
	Cell death and survival	Cell viability	Increased	2.64
	Cell death and survival	Chemotaxis of endothelial cells	Increased	2.19
	Cell death and survival	Invasion of tissue	Increased	2.14
	Cell death and survival	Cell death	Decreased	2.35
	Cell death and survival	Necrosis	Decreased	2.32
	Cell death and survival	Apoptosis	Decreased	2.06
	Cellular movement	Migration of cells	Increased	2.78
	Cellular movement	Cell movement	Increased	2.74
	Cellular movement	Cell movement of myeloid cells	Increased	2.47
	Cellular movement	Cell viability of endothelial cells	Increased	2.10
	Gene expression	Binding of DNA	Increased	2.28
MV fraction vs mock exposure (eSF)	Cell death and survival	Synthesis of prostaglandin E2	Increased	1.59
	Cell death and survival	Organization of cytoskeleton	Decreased	2.53
	Cell death and survival	Growth of embryo	Decreased	1.97
	Cellular movement	Chemotaxis of granulocytes	Increased	1.78
	Cellular movement	Transmigration of cells	Increased	1.67

^aZ-score > |1.5|. Abbreviations: eSF, endometrial stromal fibroblast; eEC, endometrial epithelial cell; MVs, microvesicles; rSP, reconstituted SP.