FIG 3.

Plasma levels of 17β-estradiol but not progesterone at 1 month postinfection correlate with VL, SPVL, and CD4⁺ T cell activation in women. 17β-estradiol (E2) was measured in the plasma at 1 month postinfection. (A and D) Correlations between plasma levels of E2 and log₁₀VL at 1 month post-EDI in women (Spearman’s correlation, P = 0.038 and r = −0.380) (A) and men (Spearman’s correlation, P = 0.241 and r = −0.184) (D). (B and E) Correlations between plasma levels of E2 and log₁₀SPVL in women (Spearman’s correlation, P = 0.006 and r = −0.486) (B) and men (Spearman’s correlation, P = 0.782 and r = −0.051) (E). (C and F) Correlations between plasma levels of E2 and CD4⁺ T cell activation at 1 month post-EDI in women (Spearman’s correlation, P = 0.0404 and r = 0.487) (C) and men (Spearman’s correlation, P = 0.582 and r = 0.131) (F). (G to I) Correlations between plasma levels of progesterone and log₁₀VL (G), log₁₀SPVL (H), and CD4⁺ T cell activation (I) at 1 month post-EDI in women (Spearman’s correlation, P = 0.640 and r = −0.12, P = 0.527 and r = −0.14, and P = 0.329 and r = 0.224, respectively).