Table 1.
Most relevant human genes involved in the inflammatory response associated with type 1 and type 2 diabetes.
| Type 2 diabetes | Type 1 diabetes |
|---|---|
| Cytokine-induced pathways | Antigen presentation |
| IFNGR1 [44] | HLA DR/DQ [7] |
| JAZF1 [52] | T cell regulation |
| MACROD1 [48] | BACH2 [10] |
| MAPK8IP1 [45] | CTLA4 [19] |
| NFE2L3 [48] | IL10 [10] |
| ST6GAL1 [46] | IL2 [10] |
| TREG/T cell regulation | IL27 [10] |
| CMIP [43] | IL2RA [22] |
| KLF14 [34] | PTPN22 [20] |
| MAP3K1 [52] | Cytokine-induced pathways |
| NLRC3 [44] | CTSH [10] |
| PTPRJ [42] | GLIS3 [10] |
| M1/M2 polarisation | HIP14 [39] |
| IFNGR1 [44] | IFIH1 [10] |
| MAEA [43] | PTPN2 [10] |
| PPARG [34] | TNFAIP3 [10] |
| TYK2 [26] |