Table 1.

Clinical details of 20 patients with SCOS.

Case	Sex	Age (year)	Presentation (duration)	Location (site in long bone)	Maxium size (cm)	Enneking Staging	ALP	LDH	Treatment	Chemotherapy Protocol	Response to chemotherapy	Margin of resection	Metastasis (interval)	Recurrence (interval)	Follow-up (duration)
1	M	21	Pain (2 m)	R prox fum (meta)	7.8	IIB	nor	nor	NC + WRA + C	DOX	good	wide	n	n	ANED (126 m)
2	F	29	Pain (2 m)	L dist fum (meta)	2.0	IIB	nor	nor	NC + WRA + C	THP	good	wide	n	n	ANED (123 m)
3	F	39	Pain (3 m)	L mid tibia (dia)	3.9	IIB	nor	nor	NC + EPR + C	DOX	good	radical	lung (95 m)	n	AWD (99 m)
4	M	48	Pain (24 m)	L prox tibia (mata)	9.9	IIB	abn	abn	NC + amputation	DOX	poor	wide	n	n	ANED (7 m)
5	M	14	Injury (2d)	R diat fum (meta)	8.6	IIB	abn	abn	NC + WRA + C + amputation	THP	poor	wide + intralesional	lung (15 m)	2 m; 8 m	DOD (16 m)
6	M	60	Swelling (5 m)	R diatal tibia (meta)	5.2	IIB	abn	nor	NC + WRA + C + amputation	THP	poor	wide	multiple (18 m)	10 m	DOD (37 m)
7	M	25	Swelling (5 m)	R prox hum (meta)	9.4	IIB	nor	abn	NC + WRA + C	DOX	good	wide	n	n	ANED (85 m)
8	M	31	Mass (4 m)	R pelvis	7.5	IIB	abn	nor	NC + Te + C + R	DOX	poor	marginal	lung (3 m)	3 m	DOD (6 m)
9	M	49	Swelling (1 m)	L dist fum (meta)	6.4	III	abn	nor	NC + WRA + C	THP	poor	wide	n	n	ANED (70 m)
10	F	15	Pain (6 m)	R prox tibia (dia)	4.4	III	nor	nor	NC + WRA + C	DOX	good	wide	n	n	ANED (52 m)
11	M	19	Mass (1 m)	R pelvis	8.9	III	abn	abn	NC + TCAE + EPR + C	VAC/IE, DOX	good	marginal	bone (4 m)	n	DOD (40 m)
12	M	17	Pain (8 m)	L pelvis	18.3	III	abn	abn	NC + amputation	DOX	poor	marginal	n	n	DOD (4 m)
13	F	20	Mass (4 m)	L mid-dist fum (dia)	5.8	IIB	nor	nor	NC + resection + C	DOX	poor	radical	n	n	ANED (53 m)
14†	M	18	Pain (1 m)	L dist fum (dia)	9.5	IIB	abn	nor	NC + WRA + C + amputation	THP	poor	wide + marginal	lung (2 m)	11 m	DOD(12 m)
15	M	25	Pain (4 m)	R pelvis	14.1	III	abn	abn	NC	DOX	poor	n	lung (1 m)	n	DOD(7 m)
16‡	M	40	Pain (9 m)	L dist fum (dia)	18.8	III	abn	abn	NC + hemipelvectomy + C	THP	poor	intralesional	lung (7 m)	n	DOD (6 m)
17	M	8	Pain (2 m)	R diat fum (dia)	4.2	IIB	abn	abn	NC + resection + C	DOX	poor	radical	lung (9 m)	11 m	DOD (17 m)
18	M	19	Pain (3 m)	R prox tibia (meta)	8.5	IIB	nor	nor	NC + resection + C	DOX	poor	radical	lung (1 m)	15 m	DOD (21 m)
19	M	14	Pain (1 m)	R prox fum (meta)	11.2	IIB	nor	nor	NC + WRA + C	DOX	good	wide	n	n	AWD (21 m)
20	M	69	Pain (12 m)	L pelvis	27.2	III	abn	abn	Te	n	n	intralesional	n	n	DOD (7 m)

Note: †family history of cancer; ‡previous history of sarcoma treated by radiation.

Abbreviations: abn, abnormal; ANED, alive with no evidence of disease; AWD, alive with disease; C, adjuvant chemothrapy; dia, diaphysis; dist, distal; DOD, died of disease; EPR, limb-salvage surgery with endoprosthetic replacement of resected bone; fum, fumer; hum, humerus; L, left; meta, metaphysis; mid, middle; m, months; n, none; NC, neo-adjuvant chemotherapy; nor, norMEmal; prox, proximal; r, radiotherapy; R, right; SCOS, small cell osteosarcoma; TCAE, transcutaneous arterial embolization; Te, tumor exclusion; WRA, wide resection and arthroplasty; y, years; DOX, doxorubicin-based osteosarcoma directed chemotherapy protocol; THP, pirarubicin-based osteosarcoma directed chemotherapy protocol; VAC/IE, an Ewing sarcoma directed chemotherapy protocol with vincristine, doxorubicin, cyclophosphamide, dactinomycin, ifosfamide and etoposide.