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. 2020 Jun 7;209(4):531–543. doi: 10.1007/s00430-020-00679-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Expression of tetraspanins in murine and human MCs. a Tetraspanin expression in different murine MC subsets. Gene expression was analyzed in following MC populations-tongue MCs (MC-To), esophagus MCs (MC-Es), trachea MCs (MC-Tr), peritoneal MCs (MC-PC), and skin MCs (MC-Sk) [45]. The heat map was generated with data from http://www.immgen.org/ choosing MCs as the cells of interest and using r gplot heatmap2. The gene expression level was determined by Affymetrix microarrays (GEO: GSE377448). Tetraspanins involved in the regulation of MC function are outlined. b Expression of tetraspanin genes in ex vivo human skin MCs isolated from three different donors. Expression data were generated by cap analysis of gene expression (CAGE) technology within the FANTOM5 project and published as Supplemental Table 3 in [61]. Plotting the extracted tetraspanin gene expression data was performed with r gplot heatmap2. Tetraspanins identified by skin MC proteome analysis [62] are outlined