Table 1.
Overview of classic definition of human, and equivalent mouse, dendritic cell subsets
| Human DC subset | Mouse DC subset | Development and function | Surface markers | Tetraspanin surface expression |
|---|---|---|---|---|
| Classical DC type 1 (cDC1) | CD8α+ DC |
Bone marrow-derived, myeloid origin Able to cross-present antigens to CD8+ T cells via MHC class I Promote Th1 and natural killer cell responses Involved in immunity against intracellular pathogens, viruses, and cancer |
CD13 CD103 CD141 CLEC9A XCR1 |
CD9 CD37 CD53 CD81hi CD82 CD151 Tspan31 |
| Classical DC type 2 (cDC2) | CD4+ DC |
Bone marrow-derived, myeloid origin Able to activate Th1, Th2, Th17, and CD8+ T cells Involved in immunity against bacteria and fungi |
CD1c CD11b CD11c SIRPα |
CD9 CD37 CD53 CD81hi CD82 CD151 Tspan31 |
| Plasmacytoid DC (pDC) | Plasmacytoid DC (pDC) |
Bone marrow-derived, lymphoid origin Secrete large amounts of IFN type 1 in response to TLR7/9 activation Mainly involved in anti-viral immunity |
CD123 CD303/CLEC-4C CD304/NRP1 |
CD9lo or CD9hi CD37 CD53hi CD81lo or CD81hi CD82lo CD151lo Tspan31 |
| Langerhans cell | Langerhans cell |
Derived from erythromyeloid progenitors found in the foetal liver Reside within epithelial layers Capable to self-renew |
CD1a CD207/Langerin E-Cadherin |
Not studied to date |
| Monocyte-derived DC (moDC) | Bone marrow-derived DC (BMDC) |
Bone marrow-derived, myeloid origin Present in tissues during steady state, but also expand populations of tissue-resident DCs during inflammation |
CD1a CD1c CD11c CCR2 |
Not studied to date |