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. 2020 Mar 2;27(9):1778–1790. doi: 10.1007/s43032-020-00175-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Quantification of manual progesterone receptor expression score in pre-therapy endometrial biopsies. a Schema: 12 progesterone-sensitive and 9 progesterone-resistant patients were included in this analysis. Pre-therapy endometrial biopsies were stained for progesterone receptor (PR). PR expression was quantified in the epithelium and stroma via ImageJ in 5 independent fields of view. Total PR expression was obtained by adding the number of PR-positive nuclei in the epithelium and stroma. H-score was determined by 2 independent investigators. b PR expression scores (PRES) were calculated using the formulae shown. Representative images of PR expression are shown in 6 independent patient samples, 3 sensitive (c–e), and 3 resistant (f–h) to hormonal therapy