Fig. 5.
Expression of estrogen receptor did not correlate with response to progesterone. a Representative images of estrogen receptor (ER) stained pre-therapy endometrial biopsies from two patients sensitive to progesterone and two patients resistant to treatment in our cohort. b ER was quantified using the visual quantification method to yield a visual ER expression score (visual ERES) and compared in sensitive vs resistant samples. Median visual ERES was not different in sensitive vs resistant samples for endometrial stroma (p = 0.15), epithelia (p = 0.47), or in total tissue (p = 0.49). c Scatterplots illustrating correlation between visual PRES and visual ERES measured in our analysis revealed that stromal PR and ER expression are moderately correlated in the stroma (rs = 0.64, p < 0.001). PR and ER expression in epithelia (rs = 0.23, p = 0.20) and in total endometrial tissue (rs = 0.21, p = 0.26) demonstrated a weak correlation