Table 2.
Association Studies of HLA‐B Alleles
| HLA‐B Allele | Study 1 | Study 2 | ||||||
|---|---|---|---|---|---|---|---|---|
| Control | Leanest NAFLD | OR | P † | Control | Whole NAFLD | OR | P † | |
| B*07:02 | 153 | 32 | 1.08 | 0.6818 | 261 | 210 | 1.12 | 0.2500 |
| B*13:01 | 23 | 7 | 1.58 | 0.3158 | 46 | 42 | 1.26 | 0.2790 |
| B*15:01 | 246 | 45 | 0.95 | 0.8031 | 407 | 332 | 1.14 | 0.0941 |
| B*15:07 | 8 | 1 | 0.65 | 1.0000 | 26 | 30 | 1.59 | 0.1024 |
| B*15:11 | 17 | 3 | 0.92 | 1.0000 | 36 | 41 | 1.58 | 0.0487 |
| B*15:18 | 50 | 9 | 0.93 | 1.0000 | 78 | 53 | 0.94 | 0.7892 |
| B*35:01 | 238 | 49 | 1.07 | 0.6766 | 366 | 281 | 1.07 | 0.4564 |
| B*37:01 | 19 | 5 | 1.36 | 0.5750 | 23 | 22 | 1.32 | 0.3662 |
| B*39:01 | 108 | 20 | 0.96 | 1.0000 | 161 | 121 | 1.04 | 0.7594 |
| B*40:01 | 155 | 29 | 0.97 | 1.0000 | 243 | 166 | 0.94 | 0.5728 |
| B*40:02 | 279 | 32 | 0.59 | 0.0054 | 340 | 236 | 0.96 | 0.6311 |
| B*40:03 | 3 | 1 | 1.73 | 0.5065 | 24 | 8 | 0.46 | 0.0711 |
| B*40:06 | 117 | 24 | 1.06 | 0.8152 | 183 | 120 | 0.90 | 0.4074 |
| B*44:02 | 15 | 1 | 0.35 | 0.4941 | 24 | 21 | 1.21 | 0.5471 |
| B*44:03 | 167 | 39 | 1.21 | 0.2862 | 360 | 246 | 0.94 | 0.4951 |
| B*46:01 | 154 | 20 | 0.67 | 0.1105 | 238 | 155 | 0.90 | 0.3205 |
| B*48:01 | 96 | 10 | 0.54 | 0.0781 | 143 | 108 | 1.04 | 0.7459 |
| B*51:01 | 221 | 48 | 1.13 | 0.4915 | 383 | 250 | 0.89 | 0.1951 |
| B*51:02 | 2 | 2 | 5.19 | 0.1255 | 9 | 10 | 1.54 | 0.3612 |
| B*52:01 | 266 | 64 | 1.25 | 0.1386 | 690 | 520 | 1.05 | 0.4708 |
| B*54:01 | 177 | 53 | 1.55 | 0.0100 | 316 | 281 | 1.25 | 0.0099 |
| B*55:02 | 23 | 2 | 0.45 | 0.4117 | 115 | 65 | 0.78 | 0.1096 |
| B*56:01 | 20 | 1 | 0.26 | 0.2330 | 50 | 25 | 0.69 | 0.1581 |
| B*56:03 | 5 | 0 | 0.00 | 1.0000 | 11 | 2 | 0.25 | 0.0875 |
| B*58:01 | 18 | 3 | 0.86 | 1.0000 | 29 | 21 | 1.00 | 1.0000 |
| B*59:01 | 51 | 13 | 1.32 | 0.3909 | 84 | 61 | 1.00 | 1.0000 |
| B*67:01 | 55 | 5 | 0.47 | 0.1112 | 51 | 27 | 0.73 | 0.2056 |
| Other | 136 | 32 | 0.81 | 0.30 | 415 | 246 | 0.81 | 0.0098 |
| Total | 2,686 | 518 | 5,112 | 3,700 | ||||
| P (multi‐allelic) ¶ , * | 0.0285 | 0.0130 | ||||||
*
P values were obtained by Fisher's exact tests for the multi‐allelic contingency table of allele numbers observed in study 1 of lean NAFLD versus TMM control and in study 2 of whole NAFLD versus control population.
†
P values of individual alleles were obtained by Fisher's exact tests for a 2 × 2 contingency table of the number of the left column allele and the number of all remaining alleles.