Table 4.

Summary of drug combinations in U-CH1 cells.

Effect level	Drug 1	Drug 2	Ratio	CI	UCL	LCL
50%	Afatinib	Palbociclib	0.0094:1	0.58	0.79	0.43
			0.038:1	0.43	0.66	0.28
			0.15:1	0.48	0.96	0.25
50%	Afatinib	AZD0530	0.025:1	0.98	2.92	0.34
			0.1:1	1.10	2.63	0.48
			0.4:1	1.05	2.36	0.53
50%	Afatinib	AZD2014	0.075:1	0.51	0.78	0.34
			0.3:1	0.57	0.84	0.39
			1.2:1	0.75	1.14	0.50
50%	Palbociclib	AZD0530	0.67:1	1.08	1.62	0.72
			2.7:1	0.95	1.14	0.79
			11:1	0.77	0.88	0.67
75%	Palbociclib	AZD2014	2:1	1.432	2.289	0.895
			8:1	1.398	1.911	1.024
			32:1	1.248	1.478	1.053
50%	AZD0530	AZD2014	0.75:1	0.61	0.77	0.49
			3:1	0.81	0.99	0.66
			12:1	1.19	1.50	0.94

Each CI was calculated at the specified effect level, along with upper and lower confidence limits (UCL and LCL). Combinations with significant synergy are indicated in bold.