Table 1.

X-ray data collection and refinement statistics.

Data collection
Space group	P21
Cell dimensions
a, b, c (Å) α, β, γ (°)	48.4, 204.9, 107.2 90.0, 92.6, 90.0
Resolution range (Å)	48.4—3.47 (3.6—3.47)
Total reflections Unique reflections Multiplicity Completeness (%) Mean I/ σ Wilson B factor (Å2) Rmeas (%) CC1/2	90,400 (6,535) 25,983 (2,227) 3.5 96.3 (79.9) 7.9 (2.2) 66.4 22.9 (89.2) 98.3 (72.4)
Refinement
Rwork Rfree	0.206 (0.215) 0.239 (0.246)
Molecules/AU Number of protein residues included in model:	12 A: 31–202 B: 31–183, 187–202 C: 31–202 D: 31–136, 140–181, 185–202 E: 30–202 F: 30–202 I: 159–208 J: 160–208 K: 159–208 L: 159–208 M: 160–208 N: 160–208
Number of non-hydrogen atoms Macromolecules Ligands	10,590 10,392 198
B-factors (Å2) Macromolecules Ligands	57.0 57.3 41.1
Structure validation
Ramachandran favored (%) Ramachandran allowed (%) Ramachandran outliers (%) Rotamer outliers (%) Clashscore	97 3 0 0.46 6
RMSD deviations
Bond lengths (Å) Bond angles (°)	0.005 0.70

Values in parentheses refer to the highest resolution shell, Ramachandran statistics were calculated with Molprobity.