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. 2020 Jul 31;3:414. doi: 10.1038/s42003-020-01151-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Top row shows a BF image of pancreatic ductal carcinoma (a), synthesized collagen using our proposed CNN network from the BF image (b), and the ground truth collagen image (c). Bottom row shows the zoomed in version of the same images as top row from the blue ROI rectangle (d–f). Scale bars: Red 200 µm and Black 100 µm.