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. 2020 Jul 31;11:3866. doi: 10.1038/s41467-020-17545-2

Fig. 3. Spatiotemporal changes of pVEGFR2, pERK, and pAkt in VEGFR2+ blood vessels during vascular regeneration in dura mater after PTI.

Fig. 3

a–c Representative images of phosphorylated VEGFR2, ERK (white arrowheads), and Akt in regenerating BVs of the dura mater at D3 after PTI in adult mice. Scale bars, 50 µm. Similar findings were observed in four mice from two independent experiments. d–f Representative images of pVEGFR2, pERK, and pAkt in VEGFR2+BVs of surrounding BVs of putative injury area (white dotted line) or injury core (IC) at D3, D7, and D14 after PTI in adult mice. Similar findings were observed in n = 3 mice from two independent experiments. Scale bars, 200 µm. Note that pERK remains elevated at D7 (yellow arrowheads) before returning to basal levels by D14.