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. 2020 Jul 31;10:12922. doi: 10.1038/s41598-020-69472-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptomic profile of colonic mucosa upon MS diet feeding. mRNA-seq was performed on RNA from colonic mucosa (n = 4 for CTR, n = 4 for MS diet). (a) Heat-map showing the differentially expressed genes between the both groups (DeSeq2 stat, p < 0.05). (b) Volcano plot showing the significantly misregulated genes in MS diet, compared to control diet. (c) Number of misregulated genes harboring CpG islands within their promoter. (d) KEGG pathways analysis of up- and down-regulated genes in MS diet group, compared to control diet-fed group. (e) Quantification of expression levels of 5 genes of interest: chitinase like 3, S100A8 (Calprotectin subunit), Fut4, B3gat1 and Lyz2 genes. Mann–Whitney test. *p < 0.05.