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. 2020 Jul 31;10:12980. doi: 10.1038/s41598-020-69547-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) S21 experimental response of the sensor for extreme case of introducing samples with 0 mM/l and 200 mM/l of glucose concentration fo the sensor. (b) Frequency shift versus glucose concentration for the extreme case of 0 and 200 mM/l glucose concentration in DI water. It could be seen that the response of the sensor is very consistent and repeatable. (c) Amplitude shift versus glucose concentration for the extreme case of 0 and 200 mM/l glucose concentration in DI water. (d) S21 response of the sensor for small variations of glucose concentration in DI water from 0 to 40 mM/l. (e) Frequency shift versus glucose concentration for concentration variations from 0 to 40 mM/l. It could be seen that great results have been achieved with very high average sensitivity of 60 kHz/1 mM/l of glucose concentration. (f) Amplitude shift versus glucose concentration for concentration variations from 0 to 40 mM/l.