Table 4.
Formulation |
Gel erosion
|
|||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Zero-order equation
(y=a+b*t) |
First-order equation
(y=a*(1-exp(-b*t)) |
Higuchi equation
(y=a+b*t 1/2 ) |
||||||||||||||||
a | b | R 2 | a | b | R 2 | a | b | R 2 | ||||||||||
G1 | -0.02 | 0.007 | 0.97 | 4.50 | 0.001 | 0.97 | -0.51 | 0.12 | 0.98 | |||||||||
G2 | -0.13 | 0.007 | 0.98 | 1938.47 | 3E-6 | 0.95 | -0.6 | 0.12 | 0.94 | |||||||||
G3 | -0.06 | 0.007 | 0.98 | 233.79 | 3E-5 | 0.97 | -0.56 | 0.12 | 0.97 | |||||||||
Formulation | Drug release | |||||||||||||||||
Zero-order equation
(y=a+b*t) |
First-order equation
(y=a*(1-exp(-b*t)) |
Higuchi equation
(y=a+b*t 1/2 ) |
||||||||||||||||
a | b | R 2 | a | b | R 2 | a | b | R 2 | ||||||||||
G1 | 0.04 | 0.006 | 0.95 | 1.65 | 0.0053 | 0.98 | -0.35 | 0.10 | 0.97 | |||||||||
G2 | -0.02 | 0.005 | 0.99 | -2.94 | -0.0016 | 0.99 | -0.41 | 0.09 | 0.97 | |||||||||
G3 | -0.02 | 0.005 | 0.97 | 29.12 | 0.0002 | 0.97 | -0.44 | 0.10 | 0.96 |