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. 2020 Jul;23(7):922–929. doi: 10.22038/IJBMS.2020.45386.10562

Table 4.

Gel erosion and drug release kinetics of the in-situ ocular gels

Formulation Gel erosion
Zero-order equation
(y=a+b*t)
First-order equation
(y=a*(1-exp(-b*t))
Higuchi equation
(y=a+b*t 1/2 )
a b R 2 a b R 2 a b R 2
G1 -0.02 0.007 0.97 4.50 0.001 0.97 -0.51 0.12 0.98
G2 -0.13 0.007 0.98 1938.47 3E-6 0.95 -0.6 0.12 0.94
G3 -0.06 0.007 0.98 233.79 3E-5 0.97 -0.56 0.12 0.97
Formulation Drug release
Zero-order equation
(y=a+b*t)
First-order equation
(y=a*(1-exp(-b*t))
Higuchi equation
(y=a+b*t 1/2 )
a b R 2 a b R 2 a b R 2
G1 0.04 0.006 0.95 1.65 0.0053 0.98 -0.35 0.10 0.97
G2 -0.02 0.005 0.99 -2.94 -0.0016 0.99 -0.41 0.09 0.97
G3 -0.02 0.005 0.97 29.12 0.0002 0.97 -0.44 0.10 0.96