Table 3.
Antioxidant activities of myricetin
| Assay | Model | Results | Ref. |
|---|---|---|---|
| Density functional theory | in silico | The bond dissociation enthalpy computed and the compound showed ionization potentials 161.4 kcal/mol. | [64] |
| Antioxidant response element (ARE) activation | in vitro | Activates Nrf2 antioxidant response element pathways and is involved in myricetin-induced expression profiling in hepatic cells. | [65] |
| Deoxyribose degradation | in vitro | Significant antioxidant activity (complex with iron) in the presence of ascorbic acid. | [8] |
| DPPH | in vitro | Myricetin/HP-β-CD inclusion complex formation enhances antioxidant activity of drugs. | [66] |
| DPPH | in vitro | Significant RSA dose-dependently | [50] |
| DPPH, ABTS | in vitro | Inhibition activity from 13.3 to 99.8% at doses of 0.03 to 1 mg/ml during 5 to 20 min. | [67] |
| DPPH, FRAP | in vitro | High RSA in DPPH assay, and intermediate ferric reducing ability in FRAP assay. | [68] |
| DPPH, FRAP, ABTS | in vitro | Mean activity for FRAP (27.2, 26.7) mmol Fe2+/L, DPPH (7.9, 9.3) mmol TEAC/L, and ABTS (9.3, 11.5) mmol TEAC/L. | [69] |
| DPPH, FRAP, ORAC | in vitro | EC50 value of DPPH, FRAP and ORAC assays were recorded as 7.60 μg, 8.86 and 12.99 mmol Trolox equivalents per gram. | [70] |
| DPPH, TPTZ, superoxide | in vitro | Myricetin and its derivatives showed IC50 value from 1.82 to 3.27 μg/mL in DPPH assay and 1.86 to 3.83 μg/mL in superoxide assay however, 1.38 to 2.89 μM equivalent to Fe2+ /mL for TPTZ assay. | [71] |
| H2O2 | in vitro | Increases hydrogen peroxide resistance in Saccharomyces cerevisiae. | [72] |
| DPPH, ROS | in vitro | 21–54% scavenging activity in DPPH assay (5–10 μg/mL) and 35–73% intracellular ROS scavenging activity (1–10 μg/mL). Significantly inhibits H2O2-induced cell death and activated antioxidant enzymes. | [73] |
| NO | in vitro | Mean scavenging activity compared to hydrophilic antioxidants. | [74] |
| ROS | in vitro | Inhibits peroxynitrite-mediated DNA damage in primary astrocytes at 5 μM. | [75] |
| ROS | in vitro | The IC30 value for inhibitory effect on triglyceride and ROS were recorded as > 150 μM and 122.7 μM. | [76] |
| ROS | in vitro | Inhibits H2O2-induced cell death and increases cell survival (65%). | [77] |
| DCFH-DA | in vivo | Inhibits ROS production in normal individuals and in patients with sickle cell anemia. | [78] |
ABTS 2,2′ azino-bis(3-ethylbenzothiazoline-6-sulphonic acid, ARE antioxidant response element, DCFH-DA dichloro-dihydro-fluorescein diacetate, DPPH 2,2-diphenyl-1-picrylhydrazyl, FRAP ferric reducing antioxidant power, NO nitric oxide, ORAC oxygen radical absorbance capacity; ROS reactive oxygen species, RSA radical scavenging activity, TEAC trolox equivalent antioxidant capacity, TPTZ tri-pyridyl triazine