Figure 1.

Diffuse large B-cell lymphoma cells display a heterogeneous sensitivity to selective BH3-mimetics. (A) Primary cells isolated from patients’ tissues were incubated with different concentrations of ABT-199, A1331852 or S63845 for 24 h before analysis of cell viability using CellTiterGlo. Experiments were performed in triplicate and data shown are the mean and standard deviation (SD) for each individual sample (n=7). (B-D) Diffuse large B-cell lymphoma cell lines were exposed to different concentrations of ABT-199 (B), A1331852 (C) or S63845 (D) before analysis of cell viability using CellTiterGlo at 72 h. Data shown are the mean and SD (n=4-6). Half maximal effective concentration (EC₅₀) values, as displayed in Table 1, are indicated for highly sensitive cell lines.