Table 1.
List of cytokine receptors and their main cytokine ligands.
| [A] | |
|---|---|
| JAK-dependent cytokine receptors and ligands | |
| Receptor family | Ligand |
| -Type I receptors | |
| Common ɣ chain [ɣc] | IL-2, IL-4, IL-7, IL-9, IL-15, IL-21 |
| TSLP receptor | TSLP |
| IL-6 family [gp-130] | IL-6, IL-11, IL-27, IL-35, LIF, OSM, CNTF, CT-1, CLC, NP, IL-31* |
| IL-12 family | IL-12, IL-23 |
| Common β chain | IL-3, IL-5, GM-CSF |
| Homodimer receptors | EPO, TPO, G-CSF, GH, PRL |
| -Type II receptors | |
| IL-13 receptor | IL-13, IL-4 |
| IFN type I | IFNα, IFNβ, |
| IFN type II | IFNɣ |
| IFN type III | IL28, IL28A, IL29 |
| IL-10 family | IL-10, IL-19, IL-20, IL-22, IL-24, IL26 |
| [B] | |
| JAK-independent cytokine receptors and ligands | |
| Receptor family | Ligand |
| -TNF receptor family | TNFα, TNFβ, LT, CD4, FasL, BAFF, Aprl, Ox40, GITR |
| -IL-17 receptor family | IL-17A, IL-17B, IL-17C, IL-17DIL-17E [IL-25], IL-17F |
| -TGF receptor family | TGFβs, Activin A, GDF1, GDF11, BMPs, Nodal |
| -Enzyme-like receptors | |
| Receptor tyrosine kinase family [RPTKs] | Ej. EGF, PDGF, VEGF, Insulin |
| Chemokine family [guanylate-cyclase-coupled receptors] | CCL, CXCL, XCL, CXC3L |
| Receptor tyrosine kinase class III | CSF-1, SCF, PDGFb, FLT3L |
| -Immunoglobulin-like family | |
| IL-1 receptor family | IL-1α, IL-1β, IL-18, IL-33, IL1F5, IL1F6, IL1F7, IL1F8, IL1F9, IL1F10 |
Cytokine receptors that depend on JAK signalling are shown in [A] and those that are JAK-independent are shown in[B].
IL, interleukin; TSLP, thymic stromal lymphopoietin; OSM, oncostatin M; LIF, leukaemia inhibitory factor; CNTF, cytokine ciliary neurotrophic factor; CT-1, cardiothropin 1; CLC, cardiothropin-like cytokine; NP, neuropoetin; EPO, erythropoietin; Tpo, thrombopoietin; G-CSF, granulocyte colony-stimulating factor; GH, growth hormone; PRL, prolactin; IFN, interferon; EGF, epidermal growth factor; PDGF, platelet-derived growth factor; VEGF, vascular endothelial growth factor; SCF, stem cell factor; M-CSF, macrophage colony-stimulating factor; FLT3L, FMS-like tyrosine kinase 3 ligand; PDGFb, platelet-derived growth factor subunit B; TNF, tumour necrosis factor. *The cytokine IL-31 does not signal through gp130 but shares the subunit [OSMRβ] with OSM, which belongs to the IL-6 receptor family.