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Tether functionalized constrained peptides. (A) Ring-closing metathesis of γ-methylated olefin tethers gives chiral all-hydrocarbon constraints. (B) Ring-closing metathesis of cysteine and γ-substituted olefin tethers gives chiral thioether constraint. (C) Thioether, sulfone, and sulfoxide peptides. (D) Addition of chloramine-T to a thioether-constrained peptide gives a sulfilimine.
