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Functionalization of tethers. (A) Oxidation of thioether gives a dual-chiral center linker. (B) Orthogonal linkage strategies (CuAAC and ring-closing metathesis) give alkene/tetrazole constraints which can be functionalized on the tether. (C) Addition of modified lipid linker gives glucagon-like peptide 2 analog. (D) Sidechain-to-terminus macrocyclization of succinic acid and diaminopimelic acid.
