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Modifications of stitched peptides. (A) Ring-closing metathesis yields bicyclic “stitched” peptide. (B) Reaction of cysteines with diyne gives di-vinyl sulfide linker that can undergo a thiol-ene reaction. (C) Sequential lactam crosslinking and ring-closing metathesis yields a bicyclic peptide. (D) Sequential lactam crosslinking and ring closing metathesis yields a cross-stitched peptide.
