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Diversification of linkages. (A) Reaction of aminooxy residue and aldehyde gives glyoxyl aldehyde. (B) Oximes are formed by addition of p-acetylphenylalanine to constraint through oxime formation. (C) Amide formation gives glucuronic acid-constrained peptide. (D) Addition of 3,3’-bis(sulfonate)-4,4’-bis (chloroacetamido)azobenzene (BSBCA) to cysteines yield a photo-isomerizable constraint.
