Table 5.

Comparison of ocular surface parameters in the two groups at each timepoint of the study

BUT	baseline	4 m	8 m	12 m	18 m
Cit-B12	10.1 ± 5.7	9.0 ± 5.9	9.7 ± 7.2	9.6 ± 4.7	9.8 ± 6.3
Placebo	8.6 ± 5.5	7.8 ± 5.0	7.4 ± 6.3	10.9 ± 6.5	9.4 ± 5.5
p	0.48	0.56	0.39	0.62	0.87
SCHIRMER	baseline	4 m	8 m	12 m	18 m
Cit-B12	15.9 ± 8.9	14.8 ± 7.1	14.7 ± 7.7	16.5 ± 9.0	14.4 ± 9.2
Placebo	14.1 ± 8.8	14.8 ± 9.2	15.5 ± 7.6	17.5 ± 11.1	16.4 ± 11.0
p	0.59	0.99	0.80	0.83	0.66
CONJUNCTIVAL STAINING
	baseline	4 m	8 m	12 m	18 m
Cit-B12	1.40 ± 0.60	1.60 ± 0.50	1.21 ± 0.42	1.11 ± 0.32	1.00 ± 0.47
Placebo	1.40 ± 0.70	1.40 ± 0.70	1.10 ± 0.57	1.13 ± 0.35	1.25 ± 0.46
p	0.99	0.43	0.60	0.89	0.22
CORNEAL STAINING
	baseline	4 m	8 m	12 m	18 m
Cit-B12	0.20 ± 0.41	0.40 ± 0.50	0.21 ± 0.42	0.05 ± 0.23	0.11 ± 0.32
Placebo	0.30 ± 0.48	0.20 ± 0.42	0.10 ± 0.32	0.01 ± 0.00	0.13 ± 0.35
p	0.58	0.26	0.43	0.33	0.89
OSDI	baseline	4 m	8 m	12 m	18 m
Cit-B12	9 ± 7	8 ± 7	7 ± 7	6 ± 5	8 ± 10
Placebo	13 ± 11	8 ± 6	7 ± 5	9 ± 7	8 ± 8
p	0.30	0.90	0.90	0.21	0.98