Table 2.
Stratification of hormonal, antropometric, clinical, radiologic, biochemical and metabolic parameters in NFAI patients by age
| Variable | Age (years) | P value | |||||
|---|---|---|---|---|---|---|---|
| < 40 N = 5 |
40–49 N = 36 |
50–59 N = 86 |
60–69 N = 86 |
70–79 N = 68 |
> 79 N = 9 |
||
| Basal serum cortisol (nmol/l) | a | a | 371 (312–439) | 375 (323–458) | 403 (324.5–457.25) | 392 (317–430) | 0.489 |
| Serum cortisol after ODST (nmol/l)a | 28 (27.6–28) | 30.3 (27.6–38) | 35.35 (30.9–39.28) | 34.05 (28.78–43.28) | 36.85 (29.28–41.33) | 30.3 (27.6–38.95) | 0.183 |
| Basal DHEAS (μmol/L) | a | 2.15 (1.7–2.8) | 1.7 (1.2–3.2) | 1.55 (0.83–2.1) | 1.3 (0.81–2.1) | 1.15 (0.53–2.45) | 0.002 |
| DHEAS after ODST (μmol/L) | a | 0.65 (0.4–1.2) | 0.9 (0.4–1.8) | 0.69 (0.3–1.2) | 0.6 (0.34–0.93) | 1.15 (0.23–1.95) | 0.041 |
| Aldosteron (nmol/l) | a | 0.18 (0.15–0.2) | 0.14 (0.1–0.23) | 0.17 (0.11–0.26) | 0.2 (0.11–0.26) | 0.1 (0.06–0.26) | 0.278 |
| Plasma Renin Activity – PRA (μg/l/h) | a | 0.41 (0.23–0.89) | 0.39 (0.15–1.28) | 0.27 (0.11–1.5) | 0.54 (0.26–1.87) | 0.31 (0.01–0.31) | 0.421 |
| TSH (mE/l) | 1.35 (1.27–1.35) | 1.39 (1.19–3.04) | 2.11 (1.24–3.26) | 6.5 (5.6–7.63) | 1.33 (0.83–4.92) | 0.46 (0.21–0.79) |
< 0.001 Pairwise comparisons 50–59 vs. > 79 P = 0.005 60–69 vs. > 79 P < 0.001 60–69 vs. 70–79 P = 0.003 40–49 vs. 60–69 P = 0.007 50–59 vs. 60–69 P = 0.024 |
| Body mass (kg) | 92.45 (54.75–143.95) | 75.3 (65.9–86) | 83.5 (72.3–93.85) | 78.5 (73.5–90) | 80.45 (65.7–88.9) | 71 (63.5–82) | 0.031 |
| BMI (kg/m2) | 35.45 (20.46–52.53) | 28.57 (24.13–31.2) | 29.04 (25.77–32.54) | 28.56 (25.8–33.35) | 28.2 (24.98–31.23) | 28.04 (25.59–30.53) | 0.715 |
| Systolic blood pressure (mm Hg) | 120 (118.5–160) | 127.5 (120–140) | 135 (120–145) | 141.5 (126.5–151.5) | 145 (126–155) | 155 (152–170) |
< 0.001 Pairwise comparisons 40–49 vs. > 79 P = 0.003 50–59 vs. > 79 P = 0.007 |
| Diastolic blood pressure (mm Hg) | 85 (80–97.5) | 77 (73–86.25) | 78 (70–87) | 75 (70–83.5) | 74 (65–80) | 88 (80–98) |
0.002 Pairwise comparisons 70–79 vs. > 79 P = 0.014 |
| Heart rate | 94 (69.5–100.5) | 80 (71.5–90) | 73.5 (68–90.25) | 72.5 (63.25–81.75) | 75 (67–87.75) | 70 (66–87) | 0.258 |
| Fasting glucose (mmol/liter) | 4.5 (4.4–5.2) | 4.9 (4.6–5.5) | 5.3 (5–6.2) | 5.55 (5.03–6.2) | 5.4 (5–6.2) | 5.6 (5.05–6.35) |
0.003 Pairwise comparisons 40–49 vs. 60–69 P = 0.015 |
| Total cholesterol (mmol/liter) | 4.5 (3.93–5.83) | 5.3 (4.88–5.83) | 5.55 (4.5–6.4) | 4.95 (4.33–5.5) | 4.7 (4.1–5.7) | 4.45 (3.58–5.58) | 0.038 |
| HDL (mmol/liter) | 1.3 (0.95–1.95) | 1.2 (1–1.43) | 1.3 (1.1–1.5) | 1.3 (1.1–1.58) | 1.2 (1.1–1.6) | 1.1 (0.95–1.15) | 0.419 |
| LDL (mmol/liter) | 2.35 (1.9–3.55) | 3.4 (3–3.9) | 3.55 (2.7–4.3) | 2.9 (2.33–3.58) | 2.8 (2.2–3.5) | 2.75 (1.95–3.65) |
0.002 Pairwise comparisons 50–59 vs. 70–79 P = 0.008 50–59 vs. 60–69 P = 0.047 |
| Triglycerides (mmol/liter) | 1.3 (0.85–4.45) | 1.6 (1.08–2.03) | 1.7 (1.3–2.2) | 1.5 (1.2–2.2) | 1.3 (1.05–2.05) | 1.55 (1.08–2.08) | 0.417 |
| Creatinine (mmol/liter) | 68.5 (61.5–75.5) | 62 (57–71.5) | 71 (64–79) | 69 (61–84) | 77 (64–95) | 72 (64.5–86.5) |
0.006 Pairwise comparisons 40–49 vs. 70–79 P = 0.001 |
| Sodium (mmol/liter) | 142.5 (139.75–143) | 141 (140–142.5) | 142 (141–143) | 142 (141–144) | 142 (140.75–143) | 143 (142.5–144) | 0.058 |
for 70 patients, data were provided as below 27.6, for 20 below 28 and for 1 below 31.3
adata available for only 1 patient or no patients
Data are given as Median (25–75%)