Table 3.
Stratification of hormonal, antropometric, clinical, radiologic, biochemical and metabolic parameters in ACS patients by age
| Variable | Age (years) | P value | |||||
|---|---|---|---|---|---|---|---|
| < 40 N = 3 |
40–49 N = 11 |
50–59 N = 40 |
60–69 N = 37 |
70–79 N = 36 |
> 79 N = 15 |
||
| Basal serum cortisol (nmol/l) | b | 339 (239-) | 372 (320.5–565.5) | 444 (362.5–510.5) | 478.5 (372–606.5) | 475 (451–604) | 0.123 |
| Serum cortisol after ODST (nmol/l)a | 56 (54.1-) | 62.3 (52–92.7) | 70.25 (57.45–93.18) | 67.9 (54.95–94.35) | 62.95 (56.8–84.28) | 67 (52.4–76.4) | 0.774 |
| Basal DHEAS (μmol/L) | b | 1.85 (0.5–3) | 0.9 (0.43–1.8) | 0.9 (0.5–1) | 0.44 (0.38–1.03) | 0.9 (0.4–1.68) | 0.445 |
| DHEAS after ODST (μmol/L) | b | 0.8 (0.2–1.2) | 0.5 (0.3–1.1) | 0.5 (0.3–0.85) | 0.5 (0.2–0.7) | 1 (0.25–1.8) | 0.716 |
| Aldosteron (nmol/l) | b | 0.31 (0.13–0.62) | 0.2 (0.11–0.28) | 0.21 (0.14–0.42) | 0.21 (0.07–0.35) | 0.23 (0.14–0.27) | 0.870 |
| Plasma Renin Activity – PRA (μg/l/h) | b | 0.21 (0.06–2.69) | 0.49 (0.15–1.06) | 0.68 (0.34–2.98) | 0.94 (0.34–2.32) | 0.61 (0.18–1.97) | 0.719 |
| TSH (mE/l) | 4.51 (2.4-) | 0.39 (0.34–1.31) | 1.37 (0.71–2.36) | 6.15 (5.73–7.48) | 0.8 (0.48–5.85) | 1.26 (0.51–3.15) |
0.001 Pairwise comparisons 40–49 vs. 60–69 P = 0.002 50–59 vs. 60–69 P = 0.021 60–69 vs. 70–79 P = 0.025 |
| Body mass (kg) | 75 (74.6-) | 67.3 (62.3–75) | 83.1 (67.5–92.2) | 73 (62.3–89.3) | 76 (67.7–80.8) | 70.15 (64.48–82.85) | 0.061 |
| BMI (kg/m2) | 27.76 (25.81-) | 25.27 (22.58–26.91) | 28.91 (25.61–31.9) | 29.34 (22.98–32.12) | 27.59 (26.13–33.46) | 28.55 (25.61–30.92) | 0.227 |
| Systolic blood pressure (mm Hg) | 122 (119–122) | 120 (115–140) | 140.5 (125.75–150.75) | 145 (112–150) | 146.5 (131.25–164.5) | 150 (135–160) | 0.038 |
| Diastolic blood pressure (mm Hg) | 82 (76–82) | 75 (75–90) | 80 (75–90) | 73 (68–85) | 75 (70–80) | 74 (65–82) | 0.037 |
| Heart rate | 91 (51–91) | 80.5 (70.25–94.5) | 78 (65–84.75) | 77 (67–84) | 70 (66.25–84.5) | 82 (71.75–90.5) | 0.637 |
| Fasting glucose (mmol/liter) | 4.7 (4.6-) | 4.6 (4.28–5.1) | 5.15 (4.93–5.98) | 5.5 (5.1–6.38) | 5.4 (5–5.98) | 6.15 (5.33–6.55) |
0.003 Pairwise comparisons 40–49 vs. 60–69 P = 0.021 40–49 vs. > 79 P = 0.006 |
| Total cholesterol (mmol/liter) | 5.4 (5.3-) | 5.05 (5-) | 5.7 (4.7–6.5) | 5 (4.1–5.9) | 4.6 (4–5.2) | 5 (3.6–5.3) |
0.019 Pairwise comparisons 50–59 vs. 70–79 P = 0.014 |
| HDL (mmol/liter) | 1.3 (1-) | 1.45 (1.3-) | 1.2 (1–1.6) | 1.3 (1.1–1.9) | 1.2 (1.1–1.5) | 1.05 (0.75–1.1) | 0.125 |
| LDL (mmol/liter) | 3.6 (3.2-) | 2.85 (2.7-) | 3.6 (2.9–4.4) | 3 (2.5–3.5) | 2.7 (2.1–3) | 2.7 (1.4–3.7) |
0.021 Pairwise comparisons 50–59 vs. 70–79 P = 0.010 |
| Triglycerides (mmol/liter) | 2.7 (1.2-) | 1.55 (1.1-) | 1.6 (1–2) | 1.6 (1.2–2) | 1.7 (1.2–2.1) | 1.9 (1.15–2.85) | 0.660 |
| Creatinine (mmol/liter) | 69 (64-) | 69 (59–74) | 67.5 (60.5–74.75) | 80 (71–90) | 74 (67–92) | 79.5 (68.5–96) |
0.006 Pairwise comparisons 50–59 vs. 60–69 P = 0.023 |
| Sodium (mmol/liter) | 141 (137-) | 141 (139–143) | 142 (140–144) | 142 (141–143) | 142 (141–144) | 141.5 (139.75–144) | 0.630 |
afor 70 patients, data were provided as below 27.6, for 20 below 28 and for 1 below 31.3
bdata available for only 1 patient or no patients
Data are given as Median (25–75%)