Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cryo-EM of the origin DNA loading reaction using ORC, Cdc6, Cdt1, and a mutant Mcm2-7. (A) A sketch for the experimental procedure. (B) Two-dimensional averages of three distinct conformations: semi-attached OCCM, pre-insertion OCCM, and mutant OCCM. The approximate range of flexibility observed between ORC–Cdc6 and Cdt1-Mcm2-7 of the semi-attached OCCM is indicated with double-headed dashed curves.
