. 2019 Jun 19;317(2):F502–F511. doi: 10.1152/ajprenal.00044.2019

Table 5.

Changes in 8-h urine NAE and its components during followup

	8-h Net Acid Excretion				8-h Urine ${NH}_{4}^{+}$ Excretion^†				8-h Urine Titratable Acid Execretion				8-h Urine ${HCO}_{3}^{-}$ Excretion
	Usual caregroup	NaCl group	${HCO}_{3}^{-}$ group	P value	Usual caregroup	NaCl group	${HCO}_{3}^{-}$ grop	P value	Usual caregroup	NaCl group	${HCO}_{3}^{-}$ grop	P value	Usual caregroup	NaCl group	${HCO}_{3}^{-}$ group	P value
Year 0	24.8 (5.1)	24.5 (4.3)	25.3 (4.2)	0.37^*	14.1 (3.1)	14.0 (2.9)	14.6 (2.9)	0.92^*	10.9 (2.5)	10.5 (2.3)	10.8 (2.2)	0.94^*	0.2 (0.1)	0.1 (0.1)	0.1 (0.1)	0.77^*
Year 5	23.9 (5.3)	24.1 (4.2)	25.4 (3.5)	0.29^*	14.3 (3.3)	14.5 (2.8)	13.5 (2.5)	0.07^*	9.7 (2.3)	9.6 (2.4)	12.4 (2.5)	0.06^*	0.1 (0.2)	0.1 (0.2)	0.6 (0.2)	0.02^*
Year 10	23.7 (5.4)	24.0 (4.0)	25.4 (3.2)	0.17^*	14.7 (3.2)	14.9 (2.9)	13.3 (2.4)	0.06^*	9.2 (2.4)	9.2 (2.4)	12.5 (2.7)	0.06^*	0.1 (0.2)	0.1 (0.1)	0.4 (0.2)	0.04^*
Difference: year 5 vs. year 0	−0.9 (13.4)	−0.4 (16.7)	0.1 (14.1)	0.06	0.2 (2.6)	0.5 (3.0)	−1.1 (3.2)		−1.2 (2.9)	−0.9 (3.2)	1.6 (4.2)	0.03	−0.1 (1.2)	0.0 (1.1)	0.5 (0.3)	0.02
P value^†	0.34	0.51	0.73		0.64	0.61	0.03		0.26	0.35	0.05		0.34	0.89	<0.01
Difference: year 10 vs. year 0	−1.1 (12.5)	−0.5 (15.8)	0.1 (14.1)	0.08	0.6 (3.7)	0.9 (2.9)	−1.3 (3.3)	0.02	−1.7 (3.1)	−1.3 (2.9)	1.7 (4.0)	0.03	−0.1 (1.1)	0.0 (1.2)	0.3 (0.2)	0.03
P value^†	0.54	0.71	0.73		0.42	0.5	0.02		0.19	0.23	0.04		0.45	0.92	<0.01
Difference: year 10 vs. year 5	−0.2 (13.2)	−0.1 (15.7)	0.0 (13.0)	0.41	0.4 (3.5)	0.4 (2.5)	−0.2 (2.5)	0.21	−0.5 (2.9)	−0.4 (2.2)	0.1 (2.6)	0.08	0.0 (1.2)	0.0 (1.0)	−0.2 (0.3)	0.18
P value^†	0.61	0.72	0.79		0.33	0.71	0.59		0.39	0.47	0.66		0.85	0.87	0.18

Values are means (SD); n = 40 participants/group. Patients with chronic kidney disease stage 2 were divided into the following three groups: usual care or treatment with oral NaCl or NaHCO₃ ( ${HCO}_{3}^{-}$ ). Mean differences were calculated as follows: mean difference = average (SD) of the year 10 value minus baseline, year 5 value minus baseline, and year 10 value minus year 5 value for each patient.

Kruskal-Wallis test for comparing three groups. All other P values were from one-way ANOVA.

^†

Signed-rank test for assessing the within-group difference between baseline and year 5, baseline and year 10, and year 5 and year 10.