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. 2019 Dec 25;123(2):670–681. doi: 10.1152/jn.00500.2019

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Fig. 1. — 5-HT-induced suppression of inhibitory postsynaptic currents (IPSCs) in principal lateral amygdala (LA) neurons. A: representative IPSC traces induced by local electrical stimulation of LA in the presence of CNQX (10 µM) and dl-APV (50 µM). Bath application of 5-HT (5 µM) reduced IPSC amplitudes. B: averaged time course of normalized IPSC amplitudes before and after 5-HT application from 10 neurons. C: modulation of IPSC amplitudes by 5-HT in 10 neurons. 5-HT significantly reduced IPSC amplitudes (control vs. 5-HT: from 119.8 ± 11.0 to 73.6 ± 12.5 pA; one-way repeated ANOVA; df = 2; F = 3.93; P = 0.03; post hoc Dunnett test, control vs. 5-HT, P = 0.017; control vs. washed out: from 119.8 ± 11.0 to 101.6 ± 11.4 pA; post hoc Dunnett test, control vs. washout, P = 0.445; n = 10). *P < 0.05.