Table 1.

Properties of low- and high-amplitude IPSCs in control conditions in the presence of drugs as well as the difference between them

	Amplitude, pA	Rise Time, ms	Decay Time, ms	Half Width, ms
Control IPSCs
High	167.2 ± 7.5*	1.91 ± 0.15	17.3 ± 1.5	14.3 ± 1.0
Low	92.3 ± 3.8*	2.21 ± 0.13	20.6 ± 1.2	16.2 ± 0.9
Drug-resistant component
High	120.0 ± 9.3*	1.76 ± 0.16	13.7 ± 1.5	12.5 ± 0.9
Low	54.7 ± 4.4*	2.05 ± 0.18	15.5 ± 1.2	14.0 ± 0.8
Drug-sensitive component
High	51.5 ± 5.2	2.64 ± 0.35	24.9 ± 3.7	19.7 ± 2.9
Low	39.1 ± 3.6	2.32 ± 0.22	28.1 ± 1.9	20.1 ± 1.6

Values are means ± SE for control conditions in the presence of drugs (5-HT or CP93129; drug-resistant component) and the difference between them (drug-sensitive component); n = 14. In cells with low- and high-amplitude inhibitory postsynaptic currents (IPSCs), the 5-HT-sensitive component had a slower decay time than the 5-HT-resistant component (P < 0.001; see detailed statistics in main text). Whereas the amplitude of the 5-HT-sensitive current did not differ between the 2 subsets of cells, that of the 5-HT-resistant component was significantly higher in cells with high than low IPSC amplitudes (P < 0.001). CP93129 also shortened the decay time of GABA_A IPSCs (P < 0.002).

^*P < 0.05, statistically significant differences between high vs. low.