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. 2020 Apr 13;318(5):F1220–F1228. doi: 10.1152/ajprenal.00517.2019

Fig. 2.

Fig. 2.

α-Endothelial epithelial Na+ channel (αEnNaC) mediates Western diet (WD)-induced aortic and renal arterial stiffening and impaired endothelium-dependent vascular relaxation. A: aortic pulse wave velocity (PWV) determined on Doppler ultrasound. B: aortic vasorelaxation response to the endothelium-dependent dilator ACh and the vascular smooth muscle-dependent dilator sodium nitroprusside. C: aortic endothelial cell stiffness as evaluated by atomic force microscopy. D: renal artery PWV using pressure-diameter analysis. cPWVinc, calculated incremental PWV. E: renal microvessel mechanical and functional experiments. Microvessel stiffness was evaluated with incremental moduli of elasticity (Inc. MofE) and cross-sectional compliance (CSC) using pressure myography in renal artery vessels. F: renal endothelial cell stiffness as evaluated by atomic force microscopy. G: renal artery wall measurements on pressure-diameter curves for internal diameter, wall thickness, wall-to-lumen ratio, and cross-sectional area (CSA). Data are expressed as means ± SD; n = 4–7. *P < 0.05 vs. control diet (CD)-fed αEnNaC+/+ mice; †P < 0.05 vs. WD-fed αEnNaC+/+ mice.