Table 1.
Characteristics of CD-fed αEnNaC+/+, WD-fed αEnNaC+/+, and WD-fed αEnNaC−/− mice
| Measure | CD-Fed αEnNaC+/+ | WD-Fed αEnNaC+/+ | WD-Fed αEnNaC−/− |
|---|---|---|---|
| Fat mass, g | 3.12 ± 0.33 (6) | 4.22 ± 0.32 (7)* | 4.41 ± 0.34 (5)* |
| Lean mass, g | 15.84 ± 0.39 (6) | 15.08 ± 0.34 (7) | 15.60 ± 0.80 (5) |
| Body weight, g | 20.30 ± 0.53 (6) | 20.62 ± 0.43 (7) | 21.25 ± 0.73 (5) |
| Mean arterial pressure, mmHg | 69.48 ± 2.29 (4) | 78.69 ± 4.58 (5) | 75.23 ± 2.69 (5) |
| Fasting glucose, mg/dL | 152.3 ± 2.2 (4) | 180.2 ± 18.3 (6) | 173.4 ± 10.3 (5) |
| Urine protein/creatinine | 1.49 ± 0.22 (8) | 2.80 ± 1.40 (7) | 1.97 ± 0.24 (5) |
| Nephrin, fold change of mRNA expression | 1.00 ± 0.143 (6) | 0.83 ± 0.08 (7) | 1.16 ± 0.11 (6) |
| Podocin, fold change of mRNA expression | 1.00 ± 0.14 (6) | 0.96 ± 0.14 (7) | 1.06 ± 0.09 (6) |
Values are presented as means ± SE; values in parentheses are numbers of animals/group. CD-fed αEnNaC+/+, control diet-fed α-endothelial epithelial Na+ channel (αEnNaC; wild-type control) mice; WD-fed αEnNaC+/+, Western diet-fed αEnNaC (wild-type control) mice; WD-fed αEnNaC−/−, Western diet-fed αEnNaC knockout mice.
*
P < 0.05 vs. CD-fed αEnNaC+/+ mice.