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Carvedilol effect on L-type Ca2+ current (ICa). A and B: effect of 1 µM (A) and 10 µM (B) on ICa. For voltage-clamp protocol, see Fig. 3. Representative ICa traces (a) and time course (b) of carvedilol effect on average peak ICa corrected and normalized for rundown. A,c and B,c: summary data for uncorrected currents in control and after 1- and 3-min carvedilol exposure. Means ± SE and individual cell data are shown (n = 8). *P < 0.02 (ANOVA). NS, not significant.
