Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 15;117(30):17864–17875. doi: 10.1073/pnas.2002449117

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published under the PNAS license.

PMC Copyright notice

Fig. 6. — A subset of idiopathic RPLs is associated with reduced TEAD4 expression in CTB progenitors. (A) Micrographs show defective villi formation in a first-trimester (7 wk) placenta from a patient suffering from idiopathic RPL. A 7 wk placenta from elective pregnancy termination was used as a control. (B) Immunofluorescence images show defective trophoblast bilayer formation and strong reduction of TEAD4 expression in CTBs in idiopathic RPL placenta, shown in A. (C) Patient-specific human TSCs were established from CTBs, which were isolated from placentae, associated with idiopathic RPL. Micrographs show efficient establishment of TSC colonies from an idiopathic RPL, which was not associated with defective placental villi formation (RPL 10, Left). In contrast, TSC establishment was inefficient from an idiopathic RPL (RPL 7), which was characterized by defective placental villi formation. We could obtain small TSC colonies only in the presence of feeder mesenchymal stromal cells isolated from first-trimester human placenta.