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Ligand-binding kinetics of JH112 and suvorexant at OX1R. Kinetic binding experiments with the radioligand [3H]SB-674042 and membranes from HEK293T cells expressing OX1R reveal a dissociation half-life of (A) 36 min for JH112 and (B) 25 min for suvorexant. Data represent mean ± SEM and the global fit from 5 to 10 individual experiments.
