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Six RBD residues of S-protein which are critical for the interaction of SARS-CoV and SARS-CoV2 with ACE2 [29,31].
| SARS-CoV | SARS-CoV2 | Status |
|---|---|---|
| Tyr-442 | Leu-445 | Different |
| Leu-472 | Phe-486 | Different |
| Asn-479, | Gln-493 | Different |
| Asp-480 | Ser-494 | Different |
| Thr-487 | Asn-501 | Different |
| Tyr-491 | Tyr-505 | Similar |
