Table 1.
Data on the assay of chloroquine extemporaneous suspensions after filtration. The extemporaneous suspensions were obtained dispersing the crushed tablets in different aqueous vehicles (i.e., purified water, CMC, FOSP). An aqueous solution made of the pure drug substance was used as a control. The data are expressed as a mean percentage and relative standard deviation (RSD%) of three batches of suspension.
| Vehicle | Filter | Drug assay (%) |
RSD (%) |
||
|---|---|---|---|---|---|
| 4 mg/ml | 25 mg/ml | 4 mg/ml | 25 mg/ml | ||
| Control | – | 101.1 | 100.7 | 1.8 | 10.9 |
| 0.2 µm, NYL | 104.2 | 102.1 | 4.6 | 1.5 | |
| 0.2 µm, PES | 101.4 | 99.6 | 1.7 | 1.3 | |
| 0.45 µm, PP | 101.2 | 100.2 | 1.0 | 0.9 | |
| 0.45 µm, PTFE | 101.5 | 99.7 | 3.1 | 0.9 | |
| Water | – | 101.3 | 106.9 | 2.4 | 10.0 |
| 0.2 µm, NYL | 99.9 | 101.2 | 1.5 | 3.4 | |
| 0.2 µm, PES | 100.4 | 102.1 | 2.1 | 3.4 | |
| 0.45 µm, PP | 100.0 | 100.9 | 0.6 | 2.5 | |
| 0.45 µm, PTFE | 100.0 | 99.3 | 0.7 | 0.3 | |
| CMC | – | 108.0 | 114.0 | 7.3 | 6.4 |
| 0.2 µm, NYL | 102.4 | 103.7 | 0.9 | 1.0 | |
| 0.2 µm, PES | 104.3 | 100.4 | 1.7 | 2.5 | |
| 0.45 µm, PP | 104.4 | 105.5 | 1.7 | 3.7 | |
| 0.45 µm, PTFE | 103.4 | 102.6 | 1.6 | 3.9 | |
| FOSP | – | 97.7 | 103.7 | 2.1 | 7.1 |
| 0.2 µm, NYL | 105.4 | 103.3 | 2.4 | 5.8 | |
| 0.2 µm, PES | 100.4 | 97.9 | 2.9 | 2.7 | |
| 0.45 µm, PP | 99.7 | 99.0 | 3.9 | 2.2 | |
| 0.45 µm, PTFE | 99.4 | 102.3 | 2.7 | 3.1 | |