TABLE III.
| Scoring system | Parameters assessed | Severity rating | Validated |
|---|---|---|---|
| EASI (Eczema Area and Severity Index) | Area affected (percentage) for 4 regions, severity for regions | Clear (0) | ✔ |
| Almost clear (0.1-1.0) | |||
| Mild (1.1-7) | |||
| Moderate (7.1-21) | |||
| Severe (21.1-50) | |||
| Very severe (50.1-72) | |||
| SCORAD (SCORing Atopic Dermatitis) | Extent (sites affected + area percentage), intensity of lesions, patient-reported intensity of itch, and sleep loss | Clear (0-9.9) | ✔ |
| Mild (10.0-28.9) | |||
| Moderate (29.0-48.9) | |||
| Severe (49.0-103) | |||
| PO-SCORAD (Patient-Oriented SCORAD) | Extent (sites affected + area percentage), intensity of lesions, intensity of itch and sleep difficulties (assessed by patient or parent/caregiver) | Clear (0-9.9) | ✔ |
| Mild (10-28.9) | |||
| Moderate (29-48.9) | |||
| Severe (49-103) | |||
| POEM (Patient-Oriented Eczema Measure) | 7 symptoms scored over past week (itch, sleep, bleeding, weeping/oozing, cracking, flaking, and dryness/roughness) | Clear/almost clear (0-2) | ✔ |
| Mild (3-7) | |||
| Moderate (8-16) | |||
| Severe (17-24) | |||
| Very severe (25-28) | |||
| Mild (0-5) | ✔ | ||
| Moderate (6-10) | |||
| Severe (11-30) | |||
| Pruritus-NRS (Pruritus Numerical Rating Scale) | Patient-reported itch, scale of 1-10 (0 = no itch; 10 = worst itch imaginable) | Mild (0-3) | No |
| Moderate (4-6) | |||
| Severe (7-10) | |||
| TIS (Three-Item Severity Scale) | Subjective evaluation of 3 intensity items (erythema, edema/papulation, and excoriations) for a representative lesion (scale of 1-3 for each) | Mild (0-2) | No |
| Moderate (3-5) | |||
| Severe (6-9) | |||
| IGA (Investigator Global Assessment) | FDA categorization of AD severity based on the investigator's subjective assessment of a representative lesion | 0 = clear | No |
| 1 = almost clear | |||
| 2 = mild | |||
| 3 = moderate | |||
| 4 = severe |
AD, Atopic dermatitis; FDA, Food and Drug Administration; QOL, quality of life.