Table 1.
Clinical Characteristics of the Study Patients
| Total (n = 111) | Pregnant (n = 31) | Nonpregnant (n = 80) | P Value | |
|---|---|---|---|---|
| Age | ||||
| Median (range), y | 32.0 (22.0–41.0) | 29.0 (24.0–41.0) | 33.0 (22.0–41.0) | .001 |
| Distribution, No. (%) | ||||
| 22~29 y | 39 (35.1) | 17 (54.8) | 22 (27.5) | .007 |
| 30~39 y | 63 (56.8) | 13 (41.9) | 50 (62.5) | .050 |
| 40~41 y | 9 (8.1) | 1 (3.2) | 8 (10.0) | .432 |
| Gestation, No. (%) | ||||
| 1~13 wk (+6 d) | 5 (4.5) | 5 (16.1) | / | / |
| 14~27 wk (+6 d) | 6 (5.4) | 6 (19.4) | / | / |
| 28~40 wk | 20 (18.0) | 20 (64.5) | / | / |
| Coexisting disorders, No. (%) | ||||
| Cardiovascular diseases | 5 (4.5) | 1 (3.2) | 4 (5.0) | .916 |
| Respiratory diseases | 1 (0.9) | 0 (0.0) | 1 (1.3) | .621 |
| Diabetes | 4 (3.6) | 3 (9.7) | 1 (1.3) | .117 |
| Malignancy | 1 (0.9) | 0 (0.0) | 1 (1.3) | .621 |
| Renal diseases | 2 (1.8) | 1 (3.2) | 1 (1.3) | .926 |
| Gastric ulcer | 1 (0.9) | 0 (0.0) | 1 (1.3) | .621 |
| Mental sickness | 1 (0.9) | 1 (3.2) | 0 (0.0) | .621 |
| Total | 15 (13.5) | 6 (19.4) | 9 (11.3) | .263 |
| Signs and symptoms, No. (%) | ||||
| Fever on admission | 64 (57.7) | 15 (48.4) | 49 (61.3) | .219 |
| Cough | 62 (55.9) | 14 (45.2) | 48 (60.0) | .158 |
| Nasal congestion | 2 (1.8) | 0 (0.0) | 2 (2.5) | .926 |
| Rhinorrhea | 1 (0.9) | 1 (3.2) | 0 (0.0) | .621 |
| Sore throat | 14 (12.6) | 1 (3.2) | 13 (16.3) | .125 |
| Myalgia or arthralgia | 9 (8.1) | 1 (3.2) | 8 (10.0) | .432 |
| Headache | 2 (1.8) | 0 (0.0) | 2 (2.5) | .926 |
| Dizziness | 3 (2.7) | 0 (0.0) | 3 (3.8) | .659 |
| Dyspnea | 35 (31.5) | 5 (16.1) | 30 (37.5) | .030 |
| Asthenia | 28 (25.2) | 1 (3.2) | 27 (33.8) | .002 |
| Digestive tract symptoms | 26 (23.4) | 3 (9.7) | 23 (28.8) | .060 |
| No symptoms | 14 (12.6) | 9 (29.0) | 5 (6.3) | .001 |
| ≥3 symptoms | 43 (38.7) | 7 (22.6) | 36 (45.0) | .030 |
| Abnormalities on chest CT, No. (%) | ||||
| Normal | 5 (4.5) | 1 (3.2) | 4 (5.0) | .067 |
| Unilateral | 32 (28.8) | 11 (35.5) | 21 (26.3) | .335 |
| Bilateral | 71 (64.0) | 16 (51.6) | 55 (68.8) | .092 |
| Not applicable | 3 (2.7) | 3 (9.7) | 0 (0.0) | .030 |
| Treatments | ||||
| Antiviral medication, No. (%) | 104 (93.7) | 29 (93.5) | 75 (93.8) | .692 |
| Oseltamivir, No. (%) | 40 (36.0) | 16 (51.6) | 24 (30.0) | .033 |
| Arbidol, No. (%) | 92 (82.9) | 25 (80.6) | 67 (83.8) | .697 |
| Ribavirin, No. (%) | 22 (19.8) | 8 (25.8) | 14 (17.5) | .325 |
| Intravenous antibiotics, No. (%) | 89 (80.2) | 29 (93.5) | 60 (75.0) | .053 |
| Antifungal medication, No. (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | / |
| Systemic glucocorticoids, No. (%) | 41 (36.9) | 20 (64.5) | 21 (26.3) | <.001 |
| Oxygen therapy, No. (%) | 37 (33.3) | 2 (6.5) | 35 (43.8) | <.001 |
| Mechanical ventilation, No. (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | / |
| Invasive, No. (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | / |
| Noninvasive, No. (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | / |
| Use of ECMO, No. (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | / |
| Use of intravenous immune globulin, No. (%) | 41 (36.9) | 7 (22.6) | 34 (42.5) | .051 |
| Use of CRRT, No. (%) | 1 (0.9) | 0 (0.0) | 1 (1.3) | .621 |
| Admission to intensive care unit, No. (%) | 1 (0.9) | 0 (0.0) | 1 (1.3) | .621 |
Abbreviations: CRRT, continuous renal replacement therapy; CT, computed tomography; ECMO, extracorporeal membrane oxygenation.