Table 3.
Sensitivity Analysis Clinical Inputs for Propofol Comparison
| Parameters | Dexmedetomidine Arm | Propofol Arm | Data Source | ||
|---|---|---|---|---|---|
| Lower Value | Upper Value | Lower Value | Upper Value | ||
| Length of stay in ICU (days) | 0.96 | 1.90 | 0.96 | 3.00 | Corbett et al,30 Maldonado et al16 |
| Duration of MV (days) | 0.23 | 0.50 | 0.25 | 0.54 | Djaiani et al,12 Srivastava et al13 |
| Sedative | |||||
| Treatment duration relative to MV duration (± hours)a | −0.59 | 6.00 | −0.44 | −0.10 | Herr et al,17 Maldonado et al,16 Srivastava et al13 |
| % that receive loading dose (%) | 90 | 100 | 0 | 100 | Dexmedetomidine inputs did not vary in published literature, varied by 10% for analysis. Corbett et al,30 Djaiani et al,12 Herr et al,17 Maldonado et al,16 Srivastava et al13 |
| Loading dose (µg/kg or mg/kg/hr)a | 0.40 | 1.00 | 0.00 | 4.00 | Corbett et al,30 Djaiani et al,12 Herr et al,17 Maldonado et al,16 Srivastava et al13 |
| Duration of loading dose (minutes)a | 10.00 | 20.00 | 0.00 | 15.00 | Herr et al,17 Maldonado et al,16 Srivastava et al13 |
| Maintenance dose (µg/kg/hr or mg/kg/hr)b | 0.31 | 0.55 | 0.04 | 2.00 | Corbett et al,30 Djaiani et al,12 Srivastava et al13 |
| Time to prepare bag (200 µg) of dexmedetomidine or vial of propofol (seconds) | 25 | 115 | 0 | 59 | Fraind et al,25 Jelacic et al,38 and van der Linden39 |
| Rescue sedation, midazolam | |||||
| % that receive rescue sedation (%) | 0 | 100 | 0 | 100 | Corbett et al,30 Maldonado et al,16 Srivastava et al13 |
| Rescue sedative dose (mg) | 0 | 1.5 | 0 | 1 | Corbett et al,30 Maldonado et al,16 Srivastava et al13 |
| Pain medication | |||||
| % treated with pain medication (%) | 90 | 100 | 90 | 100 | Inputs did not vary in published literature, varied by 10% for analysis. Corbett et al, Djaiani et al,12 Herr et al,17 Maldonado et al,16 Srivastava et al13 |
| Total dose of morphine (mg) | 2.95 | 50.30 | 6.00 | 51.60 | Corbett et al,30 Herr et al,17 Maldonado et al16 |
| Adverse events | |||||
| Occurrence of bradycardia (%) | 0 | 3 | 0 | 1 | Corbett et al,30 Djaiani et al,12 Herr et al,17 Maldonado et al,16 Srivastava et al13 |
| Occurrence of delirium (%) | 0 | 12 | 0 | 44 | Corbett et al,30 Djaiani et al,12 Herr et al,17 Maldonado et al,16 Srivastava et al13 |
| Occurrence of hypertension (%) | 0 | 12 | 0 | 4 | Corbett et al,30 Djaiani et al,12 Herr et al,17 Maldonado et al,16 Srivastava et al13 |
| Occurrence of hypotension (%) | 0 | 81 | 0 | 67 | Corbett et al,30 Djaiani et al,12 Maldonado et al,16 Srivastava et al13 |
| Occurrence of infection (%) | 0 | 10 | 0 | 10 | Inputs did not vary in published literature, varied by 10% for analysis. Corbett et al,30 Djaiani et al,12 Herr et al,17 Maldonado et al,16 Srivastava et al13 |
Notes: aDexmedetomidine: µg/kg; propofol: mg/kg/hr; bDexmedetomidine: µg/kg/hr; propofol: mg/kg/hr.
Abbreviations: ICU, intensive care unit; MV, mechanical ventilation.