. 2020 Jul 31;3:410. doi: 10.1038/s42003-020-01137-3

Table 3.

Testing seven CCT-associated loci for keratoconus-susceptibility.

Gene	Chr	Position	SNP	Effect allele	Control		Keratoconus		Odds ratio (95% CI)	P^a
Gene	Chr	Position	SNP	Effect allele	N	EAF	N	EAF	Odds ratio (95% CI)	P^a
NRXN1	2	50635086	rs13382330	C	8137	0.176	179	0.159	0.89 (0.67–1.19)	0.420
CPLX2	5	175244097	rs4242187	T	8150	0.097	179	0.070	0.70 (0.46–1.05)	0.082
CSMD1	8	2799288	rs143428993	A	8148	0.012	179	0.017	1.39 (0.61–3.14)	0.435
ADAM12	10	127905962	rs11244890	A	8156	0.211	179	0.196	0.91 (0.70–1.19)	0.491
SMAD3	15	67467507	rs12913547	T	8096	0.563	179	0.651	1.44 (1.16–1.80)	0.001^b
WWOX	16	78430702	rs6564538	T	8156	0.110	179	0.117	1.07 (0.77–1.48)	0.680
CDH13	16	83650510	rs1035533	G	8150	0.190	179	0.201	1.07 (0.83–1.39)	0.594

Chr, chromosome; EAF, effect allele frequency; SNP, single-nucleotide polymorphism; CI, confidence interval.

^aP-values derived using logistic-regression analysis.

^bP-values are statistically significant after Bonferroni’s correction.