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. 2020 Jul 31;5:14. doi: 10.1038/s41536-020-00099-8

Fig. 1. Schematic showing an overview of cardiomyocyte dedifferentiation during cardiac regeneration.

Fig. 1

Macrophages infiltrate the damaged heart to remove debris and release OSM to induce the dedifferentiation of surviving cardiomyocytes. Then, cardiomyocytes switch from the expression pattern of mature cardiomyocytes to a more immature state, enabling the cells to survive under unfavorable conditions, enter the cell cycle to proliferate, re-establish cell–cell contacts and recover their functions.