Fig. 3. Effects of a nanoscale spatial arrangement of RGD on dedifferentiation of chondrocytes.

a Schematic illustrating the experimental design. PEG hydrogel surfaces were nanopatterned with RGD peptides and then cultured with chondrocytes to explore the effect of material techniques of nanopatterning on the dedifferentiation of chondrocytes. b Schematic illustrating the effects of RGD nanopatterns on the dedifferentiation of chondrocytes. RGD with a nanospacing greater than 70 nm is beneficial for maintaining the chondrocyte phenotype. Reprinted (adapted) with permission from Li et al.¹¹⁴, copyright 2015, American Chemistry Society.