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. 2020 Jul 31;10:12976. doi: 10.1038/s41598-020-69862-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time course of the cell density within the scaffold and concordance between in-silico and in-vitro data. In (a) MCF7 cells are considered, while in (b) MDA-MB-231 cells are shown. Both the experimental (circles) and the simulated (squares) data are reported as average and standard deviation. For graphical clarity only one point every 10 h is reported for the in-silico results. Panels (c) and (d) report the distribution of the mean average percentage error (MAPE) for MCF7 and MDA-MB-231 cells respectively.