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. 2020 Jul 31;10:12976. doi: 10.1038/s41598-020-69862-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of the influence of the distance from the scaffold center on the simulated variables. The color scale in the heatmaps represents the fraction of living cells normalized with respect to the cardinality of the initial population (cell density) or the average value of a specific variable (oxygen and glucose concentrations, Young’s modulus). A bilinear interpolation has been applied. The red vertical bands visible in the glucose concentration panels correspond to media changes and thus to the replenishing of glucose to its original concentration in the cell culture media.